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The immune system is highly dynamic and regulated by many baseline characteristic factors. As such, significant variability may exist among different patient groups suffering from the same autoimmune disease AD. However, contemporary research practices tend to take the reductionist aggregate approach: they do not segment AD patients before embarking on biomarker discovery. This approach has been productive: many novel AD biomarkers have recently been discovered. Yet, subsequent validation studies of these biomarkers tend to suffer from a lack of specificity, sensitivity, and reproducibility which hamper their translation for clinical use. To enhance reproducibility in validation studies, an optimal discovery-phase study design is paramount: one which takes into account different parameters affecting the immune system biology.

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Browse studies aiming to close gender gaps. Researcher Aaron C. Meltzoff Andrew R. Krendl Anne E. Fredrickson Barry L.
A local authority has apologised after a drag queen appeared at an LGBT event in a primary school. How do you feel about a drag queen in the classroom? Renfrewshire Council said it was investigating after concerns were raised about the sexual content of social media posts by FlowJob.